Recently, the research team led by Prof. Shi Yunzhong from the School of Basic Medical Sciences at XJTU announced new achievements in the study of the pathogenesis of chronic kidney disease.
Renal arteriolosclerosis in hypertensive chronic kidney disease (CKD), is an independent risk factor for cardiovascular disease (CVD). Their research demonstrated that accumulated toxic substances in CKD will induce oxidative stress and endothelial dysfunction. Nephrotoxin damages endothelial cell function by stimulating miR-92a endothelial cellular expression, contributing to the development of cardiovascular disease. These findings provide a significant experimental evidence for understanding the pathogenesis of the renal complications of CVD and developing new therapeutic approaches.
The results can be found online in “MicroRNA-92a Mediates Endothelial Dysfunction in Chronic Kidney Disease”, Journal of the American Society of Nephrology (JASN).
Link to the article：http://jasn.asnjournals.org/content/early/2017/07/07/ASN.2016111215.full?sid=cbb05b93-cc5b-4f94-b469-2c4277b0b8f9